Evaluation Study

CALCIUM SULFATE ACTS ON MESENCHYMAL STEM CELLS: AN EXPRESSION PROFILE EVALUATION

P. Daliu1, E. Isufaj2 , M. Martinelli3 ORCID

1 Department Pharmacology, Albanian University, Tirana, Albania
2 Dental School, Albanian University, Tirana, Abania
3 Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy

Correspondence to:

Marcella Martinelli, PhD
Department of Medical and Surgical Sciences,
University of Bologna,
40138 Bologna, Italy
e-mail: marcella.martinelli@unibo.it

Annals of Stomatology 2021 September-December; 1(1): 18-24
DOI https://doi.org/10.69129/stomatol/2021v1iss1_4


Received: 3 September 2021 Accepted: 1 October 2021


Copyright © by LAB srl 2021 ISSN 2975-1276
This publication and/or article is for individual use only and may not be further reproduced without written permission from the copyright holder. Unauthorized reproduction may result in financial and other penalties. Disclosure: All authors report no conflicts of interest relevant to this article.

Download Download PDF

Abstract

Calcium sulfate, with the chemical formula CaSO₄, exists in several hydrated and anhydrous forms, including gypsum (calcium sulfate dihydrate), hemihydrate (plaster of Paris), and anhydrite. It is insoluble in water and exhibits excellent thermal stability, making it suitable for high-temperature applications. Calcium sulfate is non-toxic and environmentally friendly, contributing to its widespread use in various fields. For this reason, we studied how calcium sulfate can induce osteoblast differentiation in dental pulp-derived stem cells by measuring the expression levels of bone-related and extracellular matrix-related genes using real-time -Polymerase Chain Reaction (real-time -PCR). The obtained results showed an upregulation of the SP7 and MMP7 genes. Calcium sulfate-based materials are used in dental procedures for socket preservation, guided bone regeneration, and sinus augmentation. In periodontal surgery, calcium sulfate barriers prevent soft tissue ingrowth and promote bone regeneration around dental implants. Calcium sulfate can activate several genes of mesenchymal stem cells, stimulating bone regeneration.

Keywords: , , ,