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Evaluation Study

TITANIUM MODULATES DENTAL PULP STEM CELL DIFFERENTIATION

P. Daliu1, E. Isufaj2 , A. Pellati3

1 Department Pharmacology, Albanian University, Tirana, Albania
2 Dental School, Albanian University, Tirana, Abania
3 Department of Translational Medicine, University of Ferrara, Ferrara, Italy

Correspondence to:

Agnese Pellati, PhD
Dept of Translational Medicine
Universiti of Ferrara,
44100 Ferrara, Italy

Annals of Stomatology 2022 September-December; 2(3): 89-95
DOI https://doi.org/10.69129/stomatol/2022v2iss3_2


Received: 14 September 2022 Accepted: 10 October 2022

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Abstract

Titanium (Ti) is the most widely used material for dental, orthopedic, and maxillofacial applications because of its excellent biocompatibility and mechanical properties. Several studies have suggested that implant anchorage to bone and soft tissue can be modulated by surface characteristics. Therefore, we studied how titanium can induce osteoblast differentiation in stem cells derived from dental pulp by measuring the expression levels of bone-related genes and stem cell markers using real-time polymerase chain reaction. The results demonstrated that the upregulation of SP7 and MMP12 enhanced differentiation via the activation of stem cells. Titanium disks facilitate implant integration and promote cell activation.

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